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Serious myelomonocytic leukemia (CMML) is often a myelodysplastic syndrome/myeloproliferative overlap neoplasm characterized by sustained peripheral blood monocytosis and an inherent risk for transformation to acute myeloid leukemia (fifteen-thirty% around 3-5 a long time). Although CMML is morphologically categorized into CMML-0, 1 and 2 depending